SysBioSim

Analysis at a New Level: In Silico Analysis by SysBioSim B.V.

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Basak Tektemur Altay
CEO
basak.tektemur.altay@sysbiosim.com

As a Systems Biology Simulations company, SysBioSim provides services that utilize predictive power of mathematical modeling and simulations and ever increasing computational power. Recent developments and global efforts help us to develop more accurate models of the human metabolisms and better in silico representation of human beings by the day.

To illustrate how our computer based analyses compare to the real world empirical studies, we performed a literature based validation study. The aim of our study was to replicate the results of the actual study by using only the inputs mentioned in the study and predictive power of our models and simulations.

We selected a very interesting study relevant to dietary fat and their effects: Jurgoński A, Fotschki B, Juśkiewicz J. Dietary strawberry seed oil affects metabolite formation in the distal intestine and ameliorates lipid metabolism in rats fed an obesogenic diet. Food & Nutrition Research.

“We found this study particularly interesting, because it focuses on alternative dietary fats and their effects in basal and obesogenic diet. These are today’s hot topics. Obesogenic diet is spreading fast and the population of obese people is increasing world-wide. These lead to serious and most of the time fatal health conditions, such as cardiovascular diseases. We all want to understand whether we can alter a few things in our diet and reach favorable results.” says Mrs. Basak Tektemur Altay, CEO of SysBioSim.

“We found this study particularly interesting, because it focuses on alternative dietary fats and their effects in basal and obesogenic diet. These are today’s hot topics. Obesogenic diet is spreading fast and the population of obese people is increasing world-wide. These lead to serious and most of the time fatal health conditions, such as cardiovascular diseases. We all want to understand whether we can alter a few things in our diet and reach favorable results.” says Mrs. Basak Tektemur Altay, CEO of SysBioSim.

“It is like altering the diet of a real human being in a controlled manner. We change the inputs just like in the study which is principally same with changing a person’s diet. We simulate the same conditions with the study, however we have only done this on the computer.” says Mrs. Nilgun Yilmaz Sahin, CSO of SysBioSim and continues “We were able to replicate the same behavior for output metabolites that are defined in the empirical study and we were able to reach similar conclusions. Dietary rapeseed oil under obesogenic diet, indeed, can cause formation of certain metabolites that are accepted as indicators for colon cancer. This is in line with the results of the empirical study. Moreover, we were able to demonstrate an increase in the blood glucose levels, which is an indicator of diabetes, as an addition to the study results using only the same inputs. This actually illustrates that you can develop more knowledge and understanding with same input about your metabolite, food, drug or active ingredient of interest via in silico analyses.”

More about Literature Based Validation Study: flyer validation scientific.pdf